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Friday, March 14, 2025
Topical steroid withdrawal diagnostic criteria defined by 四虎影院researchers
Criteria may help guide treatment of dermatitis.
奥丑补迟听
Researchers at the 四虎影院 (NIH) have determined that dermatitis resulting from topical steroid withdrawal (TSW) is distinct from eczema and is caused by an excess of an essential chemical compound in the body. Scientists from NIH鈥檚 National Institute of Allergy and Infectious Diseases (NIAID) identified treatments that could be studied in clinical trials for the condition based on their potential to lower levels of the chemical compound鈥攃alled nicotinamide adenine dinucleotide (NAD+), a form of vitamin B3. The findings were published today in the Journal of Investigative Dermatology.
Dermatitis is characterized by inflammation, itching, or burning sensations on the skin, and can result from various conditions including TSW and . Eczema, also known as atopic dermatitis, is a common cause of dermatitis and affects 10 to 30% of children and 2 to 10% of adults each year in the United States. Topical steroids鈥攕pecifically glucocorticoids or topical corticosteroids鈥攈ave long been used as a first-line treatment for dermatitis caused by eczema because the drugs are safe, effective, easy to apply, and considered well-tolerated.
Some people experience dermatitis after using topical steroids for prolonged periods of time and then stopping鈥攁 condition called TSW. Diagnosing and treating this condition is difficult because TSW is not well understood. Symptoms include skin redness, burning sensations, skin heat (thermal dysregulation), itching and peeling, which can even occur on parts of the body where topical steroids were not applied. As TSW and eczema have similar symptoms, it has been difficult to distinguish the two disorders.
To better understand TSW, a team led by scientists in NIAID鈥檚 Laboratory of Clinical Immunology and Microbiology evaluated a previous survey that included 1,889 adults with symptoms similar to eczema. By dividing the participants into those with self-reported TSW and those without, the researchers identified characteristics unique to TSW. The researchers then conducted a pilot study including 16 people with symptoms consistent with TSW, 10 people with eczema but no symptoms of TSW, and 11 people without skin disease. They found that people with TSW symptoms had elevated levels of NAD+ in their blood serum and skin, while NAD+ levels were within a typical range in people without TSW symptoms.
The researchers subsequently used cultured skin cells and a mouse model to mimic TSW conditions. They found that NAD+ was produced in response to topical steroids and caused inflammation. The models suggested that administration of a drug that blocked the formation of NAD+鈥攃alled a mitochondrial complex I blockade鈥攚ould improve TSW symptoms. In a pilot study to further assess this treatment strategy, the researchers evaluated subjective responses among study participants who used the mitochondrial complex I-blocking drugs metformin, berberine, or both. After three to five months of use, most participants reported improvement in TSW symptoms.
The scientists provisionally established criteria that can be used by health care providers to identify TSW in people. People who have stopped topical steroid treatment and meet the criteria may be diagnosed by practitioners as having TSW. The researchers suggest that patients identified as having TSW could be treated using the proposed mitochondrial complex I-blocking drugs.
The results of this study may help practitioners identify TSW in patients and work towards developing safe and effective treatments. According to the researchers, more research is needed to determine whether all patients with TSW have an excess of NAD+, or if there are other features that define TSW. Additionally, the diagnostic criteria will help health care providers and researchers to better understand the prevalence of TSW and evaluate the effects of using topical steroids.
Article
N Shobnam, G Ratley, S Saksena聽et al. Topical Steroid Withdrawal is a Targetable Excess of Mitochondrial NAD+.聽Journal of Investigative Dermatology聽10.1016/j.jid.2024.11.026 (2025).
奥丑辞听
Ian Myles, M.D. M.P.H., Principal Investigator, Epithelial Therapeutics Unit in NIAID鈥檚 Laboratory of Clinical Immunology and Microbiology is available to discuss this research.
NIAID conducts and supports research鈥攁t NIH, throughout the United States, and worldwide鈥攖o study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the .
About the 四虎影院 (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. 四虎影院is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about 四虎影院and its programs, visit www.nih.gov.
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